Bilious Diseases—What are They, and Why So Called?

Observational studies: why are they so important?

Small Targets: Why are they So Difficult to Acquire?

Facilitating the acquisition of small targets is an active area of research. Despite the usefulness of the techniques proposed so far, we show why this topic can benefit from more fundamental work. We investigate three factors that might account for the observed drop in performance when selecting small targets: motor accuracy, visual legibility and quantization. Our findings suggest that visual...

Vesicular Eucrites: Where and How Did They Form and Why Are They so Rare?

T.J. McCoy, L. Wilson, G.K. Benedix, R.A. Ketcham, M. Wadhwa and A.M. Davis Dept. of Mineral Sciences, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560-0119 USA ([email protected]), Environmental Sci. Dept., Inst. of Environmental and Biological Sci., Lancaster Univ., Lancaster LA1 4YQ UK Washington University, St. Louis, MO 63130-4899 USA Dept. of Geologica...

Microsatellite markers: what they mean and why they are so useful

Microsatellites or Single Sequence Repeats (SSRs) are extensively employed in plant genetics studies, using both low and high throughput genotyping approaches. Motivated by the importance of these sequences over the last decades this review aims to address some theoretical aspects of SSRs, including definition, characterization and biological function. The methodologies for the development of S...

Oxygen uptake kinetics: Why are they so slow? And what do they tell us?

VO(2) kinetics and O(2) deficit are important determinants of exercise tolerance. In "normal" conditions convective and diffusive O(2) delivery to skeletal muscle fibers do not represent important determinants of VO(2) kinetics, whose limiting factors seem mainly located within muscle fibers. Whereas a limiting role by PDH has not been confirmed, the role of inhibition of mitochondrial respirat...